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AQA GCSE Biology Notes

2.18.3 Structure of the Kidney

The kidneys are essential organs in the human body, primarily involved in the excretory process. They play a critical role in maintaining homeostasis by filtering blood, removing waste products, and regulating electrolyte balance. This detailed exploration focuses on the kidney's complex structure, especially the cortex and medulla, highlighting their significance in kidney function.

Introduction to Kidney Anatomy

  • Location and Basic Function: The kidneys are located in the abdominal cavity, against the posterior wall, on either side of the spine. Each kidney plays a pivotal role in filtering blood to remove waste products and excess substances, crucial for maintaining the body's chemical balance.
  • Size and Shape: Each kidney is approximately 11-14 cm in length, resembling the size of a large fist. Their bean-shaped structure allows for efficient organization of internal components.
Kidneys position in the human body

Image courtesy of NIH Image Gallery

The Cortex

  • Location and Appearance: The outer layer of the kidney, the cortex appears reddish-brown and granular.
  • Structure and Components:
    • Glomeruli: These are small, ball-shaped structures composed of capillary blood vessels. Here, the initial process of blood filtration occurs.
    • Renal Tubules: Part of the nephron, these tubules are involved in reabsorbing useful substances back into the blood.
    • Nephrons: Considered the functional units of the kidney, nephrons in the cortex initiate the process of urine formation.
  • Functions:
    • Blood Filtration: Blood enters the nephrons in the cortex, where waste products and excess substances are filtered out.
    • Selective Reabsorption: Essential molecules like glucose, amino acids, and certain ions are reabsorbed here.
    • Hormone Production: Renin, an enzyme involved in regulating blood pressure, is synthesized in the cortex.

The Medulla

  • Location and Appearance: Situated beneath the cortex, the medulla has a striped appearance due to the presence of renal pyramids and columns.
  • Structure and Components:
    • Renal Pyramids and Columns: The pyramids are cone-shaped tissues that house the Loop of Henle and collecting ducts.
    • Loop of Henle: This part of the nephron plays a vital role in concentrating urine.
    • Collecting Ducts: These ducts gather urine from nephrons for excretion.
  • Functions:
    • Urine Concentration: The medulla, especially the Loop of Henle, concentrates urine by reabsorbing water and salts.
    • Water Conservation: It is vital in conserving water in the body, an essential function in maintaining homeostasis.
Diagram showing the anatomy of the kidney

Image courtesy of BruceBlaus.

Nephrons: The Functional Units of the Kidney

  • Structure and Components: Nephrons extend from the cortex into the medulla and consist of a Bowman's capsule, proximal and distal convoluted tubules, Loop of Henle, and collecting ducts.
  • Functionality in Kidney Processes: These units are responsible for the filtration of blood, reabsorption of necessary substances, and the excretion of waste in the form of urine.
Structure of nephron- showing The Proximal Convoluted Tubule

Image courtesy of CNX OpenStax

Blood Supply to the Kidneys

  • Renal Artery and Vein: The renal artery delivers unfiltered blood to the kidneys, while the renal vein transports filtered blood back to the circulation.
  • Microcirculation in Nephrons: The intricate network of capillaries within nephrons is crucial for the efficient exchange of substances during the filtration and reabsorption processes.

Urine Formation and Excretion

  • Process of Urine Formation: The process involves filtration of blood, reabsorption of essential nutrients and water, and secretion of waste products.
  • Pathway of Urine Excretion: After formation in the nephrons, urine travels through the renal pelvis, ureters, and is stored in the bladder before being excreted through the urethra.

Significance of Cortex and Medulla in Kidney Function

  • Integrated Functions for Homeostasis: The cortex and medulla work in unison to ensure effective filtration, reabsorption, and concentration of urine, pivotal for maintaining the body's internal balance.
  • Electrolyte Balance and Blood Pressure Regulation: The selective reabsorption of ions and production of hormones like renin are crucial in these regulatory processes.
  • Adaptation to Body Needs: The kidney's ability to adjust the concentration of urine based on the body's hydration status exemplifies its role in homeostasis.

Health Implications and Kidney Diseases

  • Importance of Healthy Kidneys: The efficient functioning of kidneys is vital for overall health. Disruption in kidney function can lead to significant health issues.
  • Kidney Diseases and Their Impact: Diseases like glomerulonephritis, polycystic kidney disease, and nephritis directly affect the cortex and medulla, disrupting their functions and leading to symptoms like hypertension, edema, and in severe cases, kidney failure.
Normal feet vs swollen feet in edema patient

Image courtesy of Bodiguide

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In summary, the structure of the kidney, particularly the roles of the cortex and medulla, is essential to its function as a filtration and regulatory organ. A comprehensive understanding of these structures offers valuable insights into how our bodies maintain a delicate balance of substances and highlights the importance of kidney health.

FAQ

Interlobar arteries and veins in the kidney have a fundamental role in supporting its overall function. These blood vessels are part of the kidney's intricate vascular system, crucial for delivering blood to be filtered and for carrying away filtered blood. The interlobar arteries, which branch off from the renal artery, travel between the renal pyramids within the renal columns. They extend towards the cortex, providing blood to the arcuate arteries, which in turn supply blood to the smaller cortical radiate arteries and ultimately to the nephrons for filtration. This efficient supply of blood is essential for the kidney's primary function of filtering waste and regulating various substances in the body. After filtration, the blood, now cleared of excess waste and balanced in terms of electrolyte content, is collected by the interlobar veins. These veins also travel between the renal pyramids and drain into the renal vein, which then returns the purified blood to the general circulation. The effective functioning of these arteries and veins is vital for maintaining the kidney's filtration rate and ensuring the organ's overall health and efficiency.

The renal pelvis is an integral part of the kidney's excretory function. Located at the center of the kidney, the renal pelvis is a funnel-shaped space that collects urine produced in the nephrons. After filtration and reabsorption processes in the nephrons, the urine, which now contains waste products and excess water, flows into the collecting ducts. These ducts lead into the renal pelvis. The primary role of the renal pelvis is to act as a reservoir for the collected urine before it is transported to the bladder via the ureters. The pelvis's ability to gather and temporarily hold urine is vital for controlling the rate at which urine is passed to the bladder, ensuring a steady, manageable flow. This regulation is crucial to prevent overfilling or rapid emptying of the bladder, maintaining a balanced urinary system. The renal pelvis also plays a role in initiating the reflex that triggers the muscular contractions of the ureters, which propel urine towards the bladder. These contractions, known as peristaltic movements, are essential for the efficient and controlled transportation of urine.

Renal corpuscles in the cortex are the primary sites for the initiation of urine formation. Each renal corpuscle consists of two main components: the glomerulus and the Bowman's capsule. The glomerulus is a tiny ball of capillaries where blood is initially filtered. As blood flows through these capillaries, pressure forces water and small solutes, such as ions, glucose, amino acids, and urea, out of the blood and into the Bowman's capsule. This filtration process is selective, allowing only small molecules to pass through while retaining larger molecules like proteins and blood cells within the bloodstream. The filtrate collected in the Bowman's capsule then moves into the renal tubules, where further processing occurs. In the tubules, essential substances like glucose, certain ions, and water are reabsorbed back into the bloodstream, while waste products and excess substances are left in the filtrate to form urine. Thus, the renal corpuscles play a critical role in determining the composition of the initial filtrate, setting the stage for the selective reabsorption and secretion processes that follow in the nephron, leading to the formation of urine.

The renal capsule, a tough, fibrous layer that encases the kidney, plays several crucial roles in kidney function. Firstly, it provides a protective barrier, shielding the delicate tissue of the kidney from physical damage and infection. This protection is essential given the kidney's critical role in filtering blood and maintaining homeostasis. Secondly, the capsule maintains the shape of the kidney, ensuring its structure remains intact and functional. This is important as the shape and structure of the kidney are integral to its efficient operation, particularly in the processes of filtration and reabsorption. Thirdly, the renal capsule helps to anchor the kidney in place within the abdominal cavity. This stability prevents excessive movement or displacement of the kidneys, which could disrupt their connection to blood vessels and the urinary tract, thereby impairing their function. Additionally, the pressure exerted by the capsule on the kidney tissue aids in the filtration process. The capsule's firmness helps maintain a high pressure within the glomeruli, facilitating the efficient filtration of blood into the nephrons.

The arrangement of nephrons in the cortex and medulla is strategically designed to maximise efficiency in kidney function. In the cortex, the nephrons begin with the Bowman's capsule and the glomerulus, where the initial blood filtration occurs. This filtration removes waste and excess substances while retaining essential components like nutrients and electrolytes. The filtrate then travels through the proximal convoluted tubule, which is also in the cortex, where significant reabsorption of water, glucose, and ions takes place. This step is crucial for conserving vital substances. The nephron then extends into the medulla with the Loop of Henle, where further water reabsorption occurs, significantly concentrating the urine. This structure is particularly important in regulating the body's water balance. The distal convoluted tubule, back in the cortex, fine-tunes the reabsorption and secretion processes, ensuring precise control over ion balance and pH levels. Finally, the collecting duct, traversing through the medulla, allows for further water reabsorption, regulated by hormones like ADH, fine-tuning the urine concentration before it is excreted. This arrangement allows for a sequential and highly efficient process of filtration, reabsorption, and concentration.

Practice Questions

Describe the role of the medulla in the kidney and explain how it contributes to the concentration of urine.

The medulla in the kidney plays a pivotal role in the concentration of urine. This is primarily achieved through the functioning of the Loop of Henle and the collecting ducts, both located in the medulla. The Loop of Henle extends from the cortex into the medulla and is instrumental in creating a concentration gradient. This gradient allows for the reabsorption of water and salts, which is essential for concentrating the urine. Additionally, the collecting ducts, which run through the medulla, further concentrate the urine by reabsorbing more water under the influence of the antidiuretic hormone (ADH). This process is vital for maintaining the body's water balance and ensuring that waste products are excreted efficiently.

Explain the significance of the renal cortex in kidney function, focusing on its role in filtration and reabsorption.

The renal cortex is significant in kidney function, primarily in the processes of filtration and reabsorption. The cortex houses numerous nephrons, each containing a glomerulus where the initial filtration of blood occurs. This filtration process involves removing waste products and excess substances from the blood. Following filtration, the renal tubules, which are also located in the cortex, play a crucial role in reabsorption. Here, essential substances like glucose, amino acids, and certain ions are selectively reabsorbed back into the bloodstream. This selective reabsorption is critical for maintaining the body’s chemical balance and ensuring that vital nutrients are not lost during the excretion process. Additionally, the cortex also produces renin, a hormone involved in regulating blood pressure, further underscoring its importance in overall kidney function.

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